The crisis of multilateralism accelerated by the coronavirus pandemic and a trend of de-globalisation are causing economic shifts. Many countries on the African continent are adversely affected by this development. New political and economic stimuli are needed to link regional value creation with a socio-ecological transformation in Africa. Strengthening multilateralism within the scope of a post-coronavirus social contract is necessary to carry out this transformation. The operationalisation of such a post-coronavirus social contract would be a task for the ongoing regional negotiation processes between the EU and the AU.