It is no great news that organized crime is a truly globalized, transnational business. Yet, government and governance responses remain too static and stuck within the confines of national borders. Against this background the international expert conference “Being Tough is Not Enough” was meant to reinforce the debate between politicians, experts, civil society actors and government officials on how to effectively curb transnational organized crime. While starting with a broad view on the topic and mapping the global dynamics, a particular focus was put on the issue of drug policy reform as a crucial element of any comprehensive strategy to tackle the transnational organized crime and its negative consequences for human security and democratic governance.