The Isthmus of Panama is the linking landmass between South and North America. Since the 16th century transit and migration are inherent characteristics of this region. Within the framework of increasing global interdependencies, Panama became a central global actor in the field of logistic. The increasing global complexities are also related to the increasing mobility of people. Panama’s self-perception of being the ‘global Hub of the Americas’ also reveals the need to develop more progressive tools for the challenges of international migration. In addition to Panamas unique geographical position, high level of annual asylum requests and multiple other forms of immigration revealing a necessity to act. In the field of progressive migration management, Panama has to become a regional leader. Based on a provided historical standpoint and a clear formulation of the core challenges, this paper aims to provide recommendation for action addressed to progressive actors in Panama and the region.