This study depicts trends how Kyrgyzstani entrepreneurs have adjusted to recent economic changes and identifies their main everyday challenges and opportunities within a landscape that is dominated by Russia, China and other bigger neighbors. The business case studies cover a spectrum of entrepreneurship including the import-trade with supplies for Kyrgyzstan’s sewing industry, the emergence of local manufacturing in paper products and cotton fabric, and the food-processing of sugar beet or dried fruit. The case studies illustrate various ways in which local entrepreneurs have adjusted to the fact that the previous re-export scheme of channeling China-made goods via Kyrgyzstani bazaars to larger regional markets has been fading out.