This paper analyses the role of TBTF-financial firms and their impacts on the economies of developing countries, as these firms play a key role in development finance. Their business models and profit motives drive financial processes that result in a chronic net outflow of financial resources from developing to developed countries. They contribute to financial instability and volatility in both developed and developing countries that leads developing nations to accumulate costly self-insurance through oversize external reserves. They encourage market-based indebtedness and use their position in the global financial system to avoid the worst effects of over-indebtedness, to the cost of both taxpayers in developed nations and to the majority in developing nations.