Brexit offers a good opportunity for the Czech Republic to reflect on further course of the European integration. This paper outlines three possible future scenarios of Brexit’s impact on the Czech policy towards the European Union – strengthening of ties to the European core, strengthening of relations within the Visegrád group or Czexit – which should help with deliberating the potential development of the Czech position in the EU and with setting the Czech priorities. According to the author, the question of the Eurozone entry should be of prime concern.